By Wayne Biddle
From the ravages of the Ebola virus in Zaire to outbreaks of pneumonic plague in India and drug-resistant TB in big apple urban, contagious illnesses are scuffling with again opposed to once-unconquerable smooth medication. Public quandary approximately infectious disorder is at the upward push as newspapers trumpet the arrivals of recent germs and the reemergence of previous ones.
In A box consultant to Germs, Pulitzer Prize-winning technology author Wayne Biddle brings readers head to head with approximately 100 of the best-known (in phrases of incidence, energy, old significance, or maybe literary curiosity) of the myriad pathogens that dwell in and round the human inhabitants. besides actual descriptions of the organisms and the afflictions they reason, the writer presents folklore, philosophy, heritage, and such illustrations as 19th century drawings of plague-induced panic, microscopic pictures of HIV and Ebola, and wartime posters caution servicemen opposed to syphilis and gonorrhea.
From cholera to chlamydia, TB to HIV, bubonic plague to Lyme affliction, rabies to Congo-Crimean encephalitis, anthrax to Zika fever, and again to sturdy previous rhinitis (the universal cold), A box advisor to Germs is either a convenient reference paintings to raised comprehend today's headlines and a desirable examine the outstanding impression of micro-organisms on social and political history.
Winner of the yankee clinical Writers Association's Walter C. Alvarez Honor Award.
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Extra info for A Field Guide to Germs (Revised and Updated Edition)
Integrins have three activation states, basal avidity, low avidity and high avidity. They play a pivotal role in immunity, cancer, homeostasis and wound healing, which is mediated bidirectionally via transmitting signals across the plasma membrane. The affinity to the ligand is regulated by global conformational changes, which relate to the interdomain and intradomain shape shifting. The downward movements of the C-terminal helices play a critical role in integrin conformational signaling. 20 1 Overview of the Immune Response Selectins Selectins are a family of membrane glycoproteins that are divalent cation-dependent and bind to specific carbohydrates containing sialylated moieties.
975:57–67. Rothenberg M, Hogan S. 2006. The eosinophil. Ann Rev Immunol. 24:147–174. Sallusto F, Lanzavecchia A. 2002. The instructive role of dendritic cells on T cell responses. Arthritis Res. 4:S127–S132. Schwarz BA, Bhandoola A. 2006. Trafficking from the bone marrow to the thymus: a prerequisite for thrombopoiesis. Immunol Rev. 209:47–57. Springer TA. 1990. Adhesion receptors of the immune system. Nature. 346:425–434. Springer TA. 1993. Adhesion receptors in inflammation: A pr´ecis. In: Thomas ED, Carter SK, Eds.
Chapter 2 Role of Cytokines Introduction Cytokines are small glycoproteins produced by a number of cell types, predominantly leukocytes, that regulate immunity, inflammation and hematopoiesis. They regulate a number of physiological and pathological functions including innate immunity, acquired immunity and a plethora of inflammatory responses. The discovery of cytokines was initiated in the 1950s, but the precise identification of their structure and function took many years. The original discoveries were those of IL-I, IFN and nerve growth factors (NGFs); however, these cytokines were purified and given their names years later.
A Field Guide to Germs (Revised and Updated Edition) by Wayne Biddle