By Frank J. Dlxon (Ed.)
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Additional info for Advances in Immunology, Vol. 38
VII. Zr Gene Control of T Cell-T Cell Interactions . . . . . . . . . . . . . . . A. (Tyr,Glu)-DL-Ala--Lys[(T,G)-A--L]and Helper Factors . . ... B. “Ia-Like” Molecule5 Expressed by T Cells . . . . . . . . . . . . . . . C. Evidence for and against MHC-Restricted T Cell-T Cell Interactions . . . VIII. Zr Gene Control of Cytotoxic T Cell Responses . , , . . . . , , . , . . , , . . . . A. Introduction . . . . . , . . . . . . . .
The major concept was that each individual possessed a unique set of macromolecules because of the genetic polymorphisms that exist within the species. If one form of a pleiomorphic determinant on a macromolecule happened to structurally mimic a determinant on a foreign antigen, then tolerance to the self determinant would preclude that individual from responding to the foreign determinant (nonresponder). In contrast, another individual of the same species, who possessed a difierent allelic form of the self determinant, would be able to respond to the foreign determinant (responder).
126, 2117. Hiinig, T. , and Bevan, M. J. J. E x p . Med. 155, 111. , Munro, A. , and McConnell, I. (1982). Nature (London) New Biol. 236, 52. Infante, A. J . , Infante, P. , and Fathman, C. G . J. Exp. Med. 155, 1100. , Hutton, J. , Boyse, E. , and Old, L. J. (1972). Transplantation 13, 239. Janeway, C. , and Binz, H. (1976). Scand. J. Zmmunol. 5, 993. , Morse, H. , Carbone, A,, and Palmer, E. (1985). Science (in press), MHC-RESTRICTED RECEPTOR ON T CELLS 27 Jones, N . , Strorninger, J. , and Woody, J.
Advances in Immunology, Vol. 38 by Frank J. Dlxon (Ed.)