By Frank J. Dixon (Ed.)
Meant for researchers in immunology, mobile biology, virology and medication, this publication offers details on such subject matters as cytokine gene legislation, and animal types for obtained immunodeficiency syndrome.
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Additional resources for Advances in Immunology, Vol. 52
However, every antigen is not necessarily an immunogen: only antigens that effectively trigger an active immune response are called immunogens. In addition, every antigen is not necessarily a pathogen: only antigens that trigger damages or disease in the host are said to be pathogens. And fi nally, as will become clearer in the rest of this book, an antigen is not necessarily foreign. According to this defi nition, there is immunity, properly speaking, only when there is a biochemically specific reaction between an antigen (ligand) and receptors carried by the immune system’s actors.
Plant resistance proteins fall into two categories. The fi rst category is a family of proteins containing a nucleotide binding site 26 I M M U NOL O G Y, S E L F A N D NON S E L F (NBS) and leucine-rich repeat (LRR) domains. In Arabidopsis, there are more than 150 proteins from the NBS-LRR family (Dangl and Jones 2001). NBS-LRR proteins also exist in animals, where they make up an important part of the innate immune system (Rairdan and Moffett 2007). The second category comprises proteins with extracellular leucine-rich repeat (“eLRR”) domains.
Therefore, understanding the precise defi nition of “self ” and “nonself,” as well as the foundations and subsequent evolutions of the self-nonself theory, requires 46 I M M U NOL O G Y, S E L F A N D NON S E L F a conceptual analysis of Burnet’s thought. Indeed, it seems crucial to question it in order to grasp what this theory was in the 1950s, and what it has become today. I shall explore the different meanings of the terms “self ” and “nonself ” while showing how the founder of the self-nonself theory, Burnet, evolved on the question of knowing how to defi ne the self from an immunological point of view.
Advances in Immunology, Vol. 52 by Frank J. Dixon (Ed.)