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Nature204:998 14. Noauthor. 1965. Histocompatibility testing 1965. Series Haematologica. Vol. 11. Copenhagen:Munksgaard 15. Rapaport, F. , Lawrence, H. , Converse,J. M, Tiller, W. , Mulholland,J. H. J. Clin. Invest. 41:2166 16. J. J. 1967. A proposal for international cooperation in organ transplantation: Eurotransplant. In: 27 Histocompatibility Testing 1967. Baltimore: Williams& Wilkins 17. , Miggiano, V. , Ceppellini,R. Cell mediated lympholysisin manafter sensitization of effector lymphocytesthrough mixed leukocytecultures.

J. 6. Swain,S. , Bradley,L. , Weinberg, hnmunol. 140:1555-60 A. , Duncan,D. , Hedrick, S. , 16. Fiorentino, D. , Bond,M. , MosDutton, R. , Huston,G. 1991. Helper mann,T. R. 1989. Twotypes of mouse T-cell subsets: Phenotype,function and T helper cell. IV. Rev. 123: by Thl clones. J. Exp. 170: 2081115-44 95 7. Torbett,B. , Laxer,J. , Glasebrook, 17. Mosmann,T. , Schumasher, J. L. FrequenciesofT cells secretStreet, N. , ing IL-2 and/or IL-4 amongunprimed Fong, T. A. , Bond, M. , Moore, CD4+populations.

Comparableresults have been reported by other investigators (45, 46). This inhibition is not due soluble mediators, and anti-IFN-v mAbdoes not reverse the effect. It should be noted that the proliferative response of Tul clones stimulated with immobilized anti-CD3 mAbin the absence of accessory cells is suboptimal; proliferation is augmentedsignificantly when T-depleted syngeneic spleen cells are added to cultures (T. Gajewski, unpublished observations), an effect observed by other investigators (45, 46).

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