Annual Reviews's Annual Review of Immunology Volume 16 1998 PDF

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Extra resources for Annual Review of Immunology Volume 16 1998

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The results of early studies indicated that IL-1β and IL-1Ra possess an identical β-pleated sheet structure and that residues in the common open-faced surface of both molecules bind to the same site on the type I IL-1 receptor (5). However, IL-1β interacted with two additional sites on the receptor, a β-bulge between strands 4 and 5 and a region around aspartic acid at residue 145. These interactions were thought to be responsible for the difference in biologic activity between IL-1β and IL-1Ra.

Arend WP. 1991. Interleukin 1 receptor antagonist. A new member of the interleukin 1 family. J. Clin. Invest. 88:1445– 51 3. Dinarello CA. 1991. Interleukin-1 and interleukin-1 antagonism. Blood 77: 1627–52 4. Dinarello CA, Thompson RC. 1991. Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Immunol. Today 12:404–10 5. Arend WP. 1993. Interleukin-1 receptor antagonist. Adv. Immunol. 54:167–227 6. Lennard AC. 1995. Interleukin-1 receptor antagonist. Crit. Rev. Immunol. 15:77– 105 7.

Biol. Chem. 269:12874–79 Schreuder HA, Rondeau JM, Tardif C, Soffientini A, Sarubbi E, Akeson A, Bowlin TL, Yanofsky S, Barrett RW. 1995. Refined crystal structure of the interleukin-1 receptor antagonist. Presence of a disulfide link and a cis-proline. Eur. J. Biochem. 227:838–47 Vigers G, Anderson L, Caffes P, Brandhuber BJ. 1997. Crystal structure of the type-1 interleukin-1 receptor complexed with interleukin-1β. Nature 386:190–94 Schreuder H, Tardif C, Trump-Kallmeyer S, Soffientini A, Sarubbi E, Akeson A, Bowlin TL, Yanofsky S, Barrett RW.

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Annual Review of Immunology Volume 16 1998 by Annual Reviews


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