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7:250–61 Stiernholm NBJ, Berinstein NL. 1994. Immunoglobulin somatic variation; studies of receptor editing in a human B cell lymphoma. Leuk. Lymphoma 12:333–41 Siminovitch KA, Moore MW, Durdik J, Selsing E. 1987. The human kappa deleting element and the mouse recombining segment share DNA sequence homology. Nucleic Acids Res. 15:2699–705 Moore MW, Durdik J, Persiani DM, Selsing E. 1985. Deletions of kappa chain constant region genes in mouse lambda chain-producing B cells involve intrachromosomal DNA recombinations similar to V-J joining.

Genomic organization of the genes encoding mouse T-cell receptor alphachain. Nature 316:832–36 Takeshita S, Toda M, Yamagishi H. 1989. Excision products of the T cell receptor gene support a progressive rear- 42 31. 32. Annu. Rev. Immunol. 18:19-51. org by HINARI on 09/01/07. For personal use only. 33. 34. 35. 36. 37. 38. NEMAZEE rangement model of the alpha/delta locus. EMBO J. 8:3261–70 Petrie HT, Livak F, Burtrum D, Mazel S. 1995. T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production.

Lymphoma 12:333–41 Siminovitch KA, Moore MW, Durdik J, Selsing E. 1987. The human kappa deleting element and the mouse recombining segment share DNA sequence homology. Nucleic Acids Res. 15:2699–705 Moore MW, Durdik J, Persiani DM, Selsing E. 1985. Deletions of kappa chain constant region genes in mouse lambda chain-producing B cells involve intrachromosomal DNA recombinations similar to V-J joining. Proc. Natl. Acad. Sci. USA 82:6211–15 Muller B, Stappert H, Reth M. 1990. A physical map and analysis of the murine C kappa-RS region show the presence of a conserved element.

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