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Additional info for Annual Review of Immunology Volume 9 1991
Carpen, J. Caulfield, M. L. Dustin, and T. A. Springer, in preparation). The basis of the difference between lymphocytesand natural killer cells in binding to the GPI-anchoredform of LFA-3is not understood. However,CD2is associated with different signal transducingmechanisms in natural killer cells than in T lymphocytes (153, 154). Whetherlateral immobilization of LFA-3is ever used as regulatory mechanism by cells remainsto be seen. Regardless, this model system demonstratesthe importance of lateral mobility for mechanisms of cell adhesion.
Selectins are family of surfacc molecules possessing three different structural motifs. Selectins possess a single N-termlnal (extracellular) lectin motif followed by a single epidermal growth factor repeat and a varying numberof short consensus repeat homologyunits as found in complement-binding proteins (70-75). Mel 14 is a selectin on lymphocytes that has a critical role interaction of lymphocytes with peripheral lymph node endothelial cells (71, 73-76). Other known members of this family are involved in the interaction ofleukocytes and platelets with each other and with endothelial cells (72, 77).
Annu. Rev. Immunol. 9:1-27. org by HINARI on 08/29/07. For personal use only. 70. 71. 72. 73. BENACERRAF responses in vitro. III. Tolerogenicproperties of the terpolymer L-glutamic acid6°-L-alanine3%L-tyrosine ~° (GAT) for ~pleen cells from nonresponder (H2~ and H-2q) mice. J. Exp. Med. 140: 172-84 Kapp, J. , Pierce, C. , Benacerraf, B. 1974. Genetic control of immuneresponses in vitro. V. Stimulation of suppressor T cells in nonresponder mice by terpolymer L-glutamic acid6°-L-tyrosine ~° (GAT)~.
Annual Review of Immunology Volume 9 1991 by Annual Reviews