Download e-book for iPad: Anti-aging in Ophthalmology: Special Issue: Ophthalmic by K. Tsubota

By K. Tsubota

ISBN-10: 3805595743

ISBN-13: 9783805595742

Some of the ailments resulting in blindness resembling cataract, glaucoma, diabetic retinopathy and age-related macular degeneration correlate with the patient's age. Even genetic problems similar to retinitis pigmentosa will be thought of 'premature getting older of the retina', and additional, dry eye or presbyopia, which may dramatically impact caliber of imaginative and prescient, are age comparable. Antiaging learn turns into a growing number of vital nowadays, even though the basics aren't but common commonplace within the medical institution; although, reactive oxygen species keep watch over appears the start. sooner or later, a formal vitamin, together with calorie restrict or antioxidant nutrition components, antioxidant vitamins, workout in addition to drug intervention may well play an essential function within the fight opposed to age-related eye problems. This quantity exhibits the newest advancements and may be a helpful replace almost about age-related eye ailments not just for ophthalmologists, but in addition for basic physicians.

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Extra resources for Anti-aging in Ophthalmology: Special Issue: Ophthalmic Research 2010, Vol. 44, No. 3

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Invest Ophthalmol Vis Sci 2004; 45: 4388– 4399. 43 Downs JC, et al: Three-dimensional histomorphometry of the normal and early glaucomatous monkey optic nerve head: neural canal and subarachnoid space architecture. Invest Ophthalmol Vis Sci 2007; 48: 3195– 3208. 178 44 Johnson EC, et al: The effect of chronically elevated intraocular pressure on the rat optic nerve head extracellular matrix. Exp Eye Res 1996;62:663–674. 45 Quigley HA, Brown A, Dorman-Pease ME: Alterations in elastin of the optic nerve head in human and experimental glaucoma.

Alterations in the cellular nucleotide pool generate a promutagenic state and inefficient DNA repair and synthesis propagating mitochondrial mutagenesis [53]. The first identified mitochondrial disease associated with the dNTP pool is mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), which is characterized by ocular defects such as ophthalmoplegia and pigmentary retinopathy [54]. It is of further interest to note that nucleotide imbalance, such as that observed in MNGIE, is highly mutagenic and has the potential to impair the DNA repair processes [55].

Med Sci Sports Exerc 2009;41: 1566–1572. , USA Key Words Mitochondria ؒ Ocular function ؒ Reactive oxygen species Abstract Mitochondria are critical for ocular function as they represent the major source of a cell’s supply of energy and play an important role in cell differentiation and survival. g. g. age-related macular degeneration, cataract and diabetic retinopathy). Mitochondrial DNA (mtDNA) instability is an important factor in mitochondrial impairment culminating in age-related changes and pathology, and in all regions of the eye mtDNA damage is increased as a consequence of aging and age-related disease.

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Anti-aging in Ophthalmology: Special Issue: Ophthalmic Research 2010, Vol. 44, No. 3 by K. Tsubota


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