By Giancarlo Balercia, Loredana Gandini, Andrea Lenzi, Francesco Lombardo
This e-book specializes in using a number of molecules with antioxidant homes within the remedy of significant male genital tract issues, specifically male infertility, erectile disorder, and accent gland an infection. The assurance additionally contains dialogue of pathophysiology, the molecular foundation of male infertility, and the reason to be used of antioxidants, with specific recognition to coenzyme Q10 and carnitine. Oxidative pressure happens whilst the construction of reactive oxygen species, together with loose radicals, exceeds the body’s normal antioxidant defences, resulting in mobile harm. Oxidative tension is found in approximately half all infertile males, and reactive oxygen species can produce infertility either via destructive the sperm membrane, with effects for sperm motility, and via changing the sperm DNA. there's hence a transparent intent for using antioxidant remedies inside andrology, and diverse in vitro and in vivo reviews have indicated that many antioxidants certainly have necessary affects. In supplying a close and updated review of the topic, this booklet may be of curiosity to either practitioners and researchers in andrology, endocrinology, and urology.
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Additional info for Antioxidants in Andrology
Carnitine may in fact act as a scavenging mechanism for reactive oxygen species (ROS) in the prevention of some forms of idiopathic male infertility. The efficacy of the use of various antioxidants as a therapeutic tool has been demonstrated in various controlled studies on selected caseloads of infertile subjects . There is ample experimental evidence to suggest that carnitine has a protective role against oxidative stress . The mechanism through which it expresses its antioxidant properties is not yet completely clear, although there is considerable evidence that its main protective action is in the membrane systems.
Finally CoQ10 has been shown to have an important effect also during pregnancy: Teran et al.  reported the results of a CoQ10 supplementation in reducing the risk of preeclampsia. Pregnant women at increased risk of preeclampsia either received 200 mg of CoQ10 or placebo daily from 20 weeks of pregnancy until delivery. 4 %). Preeclampsia is a common disorder of human pregnancy in which the normal haemodynamic response to pregnancy is compromised. It remains a leading cause of maternal morbidity and mortality and is associated with a significant increase in perinatal mortality.
The previous application of TOSC assay in andrology leads us to show a reduced antioxidant efficiency in seminal fluid of infertile men with a significant correlation between the scavenging capacity toward hydroxyl radicals and parameters of sperm cell motility . Despite oxidative stress being well recognized as a cause of male infertility, the use of antioxidants as a treatment is still debated, and it is considered as a “supplementation” therapy, rather than an etiological or physiopathological therapy, since no clear correlation has been investigated between a real deficiency of a specific antioxidant and the effect of oral supplementation.
Antioxidants in Andrology by Giancarlo Balercia, Loredana Gandini, Andrea Lenzi, Francesco Lombardo